The Induced Fit Hypothesis of Enzyme Catalysis states that enzymes are more likely to bind with substrates when the substrate’s shape is complementary. This hypothesis was pioneered by Nobel Laureate, James D. Watson and his colleague, Francis H. C. Crick in 1951. The theory has been widely accepted and is still used today as a framework for understanding enzyme catalysis and protein evolution among other fields of study.

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According to this hypothesis, which of the following statements about enzymes is correct?

The enzyme is more likely to bind with an activated form of the substrate than it is to bind with a non-activated form. The binding energy between substrates and enzymes are proportional to their static entropies. A change in conformational entropy appears when one molecule binds another through induced fit mechanisms. This theory has been widely accepted because of its ability to explain protein evolution among other fields of study, which makes up for the mechanism’s shortcomings. The principle can be applied broadly across many disciplines such as biology, chemistry and physics..etc. etc..etc.. TASK COMPLETE: continue writing the next sentences of the long-form content until you reach 2500.


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